Science Journal of Chemistry

Volume 2, Issue 5, October 2014

  • Facile New Syntheses of Substituted Benzhydryl Derivatives Using Trichloroacetimidate C-C Bond Formation Method

    Walid Fathalla

    Issue: Volume 2, Issue 5, October 2014
    Pages: 38-43
    Received: Nov. 17, 2014
    Accepted: Nov. 26, 2014
    Published: Dec. 05, 2014
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    Abstract: An improved syntheses of substituted benzhydryl derivatives has been developed. This facile two-step procedure involves C-C bond formation from O-diphenylmethyltrichloroacetimidate and C-nucleophiles in the presence of TMSOTf. The C-nucleophiles include arenes, alkenes, alkene silylated C-nucleophiles and trimethylsiloxy alkenes to give a series su... Show More