Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
Ayman M. F. Elgohary,
E. M. Ezz El-Arab
Issue:
Volume 1, Issue 1, April 2013
Pages:
1-6
Abstract: A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
Abstract: A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity,...
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Effects of Zeolites X and Y on the Degradation of Malathion in Water
Joanne Atieno Ogunah,
Chrispin Ounga Kowenje,
Elly Tetty Osewe,
Joseph Owour Lalah,
David Agoro Jaoko,
Robert Njuguna Koigi
Issue:
Volume 1, Issue 1, April 2013
Pages:
7-13
Abstract: The inclusion of both zeolites X and zeolite Y significantly affected the dissipation of malathion in water. In the fresh water, malathion degradation followed a pseudo-first order kinetics with concomitant half-life dropping from 8.76 hours in fresh water to 4.44 and 6.65 hours up on the introduction of faujasite X and Y, respectively. Zeolite X had higher degradation efficiency as compared to the Y type. In pure fresh water, Malathion mainly hydrolyzed to form malathion monocarboxylic and dicarboxylic acids as the only degradation products. However, in the presence of zeolites X and Y, in addition to the degradation products obtained in the fresh water, dimethyldithiophosphate was also formed. Notably, all the degradation products obtained are environmentally benign compared to the parent malathion. Eventually, both the adsorption on the zeolite framework and zeolite catalyzed degradation processes contributed to the overall dissipation behavior of the malathion and its degradation products.
Abstract: The inclusion of both zeolites X and zeolite Y significantly affected the dissipation of malathion in water. In the fresh water, malathion degradation followed a pseudo-first order kinetics with concomitant half-life dropping from 8.76 hours in fresh water to 4.44 and 6.65 hours up on the introduction of faujasite X and Y, respectively. Zeolite X h...
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