Science Journal of Chemistry

Volume 2, Issue 6, December 2014

  • Synergism of Metal and Organocatalysis in Condensation Reactions of Aromatic Aldehydes with Anilines Affording Imines: Effect of Catalysts on the Base of a Supported Cerium(III) and Proline

    Eva Havránková, Patrik Pospíšil, Pavel Pazdera

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 1-8
    Received: Aug. 26, 2014
    Accepted: Sep. 06, 2014
    Published: Sep. 17, 2014
    DOI: 10.11648/j.sjc.s.2014020601.11
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    This article belongs to the Special Issue Green Chemistry: Synthesis and Its Uses
    Abstract: Condensation reactions between 4-X-benzaldehydes (X = NO2, H, OCH3) and 4-Y-anilines (X = NO2, H, OCH3) catalyzed by new catalyst, i.e. Ce (III) supported on weakly acidic cation-exchanger resin of polyacrylate type and/or by proline as organocatalyst giving 4-Y-N-[(E)-(4-X-phenyl)methylidene]anilines, were studied. It was found that the both of th... Show More
  • Large Scale Process to Prepare Highly Pure Bosentan Monohydrate

    Amala Kompella, Srinivasu Kasa, Veera Swami Balina, Subhash Kusumba, Bhujanga Rao Kalisatya Adibhatla, Pulla Reddy Muddasani

    Issue: Volume 2, Issue 6-1, December 2014
    Pages: 9-15
    Received: Aug. 28, 2014
    Accepted: Sep. 15, 2014
    Published: Sep. 23, 2014
    DOI: 10.11648/j.sjc.s.2014020601.12
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    This article belongs to the Special Issue Green Chemistry: Synthesis and Its Uses
    Abstract: Described is an improved process for the preparation of highly pure Bosentan monohydrate (>99.8% HPLC purity) 1 with pyrimidinone 8 and the dimer 9 impurities to less than 0.10% of HPLC analysis. The present work also provides processes for the preparation of pyrimidinone 8 and dimer 9 impurities.