Volume 7, Issue 4, August 2019, Page: 77-81
2-oxo-2H-chromen-3-yl Propionate and 2-oxo-2H-chromen-3-yl Acetate: Short-step Synthesis, Characterization and Fluorescence Properties
Jules Yoda, Department of Medicine, Traditional Pharmacopeia and Pharmacy / Research Institute for Health Sciences, Ouagadougou, Burkina Faso; Laboratory of Molecular Chemistry and Materials, University Joseph KI-Zerbo, Ouagadougou, Burkina Faso
Salfo Ouédraogo, Department of Medicine, Traditional Pharmacopeia and Pharmacy / Research Institute for Health Sciences, Ouagadougou, Burkina Faso
Adama Saba, Laboratory of Molecular Chemistry and Materials, University Joseph KI-Zerbo, Ouagadougou, Burkina Faso
Received: Sep. 20, 2019;       Accepted: Oct. 14, 2019;       Published: Oct. 23, 2019
DOI: 10.11648/j.sjc.20190704.12      View  62      Downloads  29
Abstract
Natural or synthetic coumarins are of great interest, since many of them show prominent biological activity and photochemical characteristics. In particular, hydroxycoumarins and their derivatives have been extensively studied in various fields such as biology, medicine, physics and chemistry. Among the well-known compounds is 7-hydroxycoumarin, also known as umbelliferone and 4-hydroxycoumarin. Against 3-hydroxycoumarin and its derivatives are less known and studied. In this study, new acyl derivatives were synthesized from 3-hydroxycoumarin or chromen-2,3-dione its tautomeric form and chloride acid in the presence of an appropriated base. The structures of the newly obtained compounds were confirmed by elemental analysis, mass spectrometry (MS), IR and NMR spectrometry and X-ray diffractometry. In addition, the fluorescence properties of the titre compounds were also studied in both liquid and solid state. In liquid media, the study concerned their behaviour in fluorescence emission spectrometry in 6 solvents of different polarities. The new heterocyclic compounds have been successfully synthesized. Fluorescence spectrum analyses show that these compounds are all fluorescent in both solid and liquid state with varying fluorescence intensities (IF). On solvatochromic analyses, it appears that the behaviour of the spectrum depends strongly on the solvent. The fluorescence intensity and wavelength (λem) vary depending on the nature of the substituent (R) and especially that of the solvent. It should also be noted that chloroform is the solvent that most enhances the fluorescence of the compounds.
Keywords
Coumarins, 3-Hydroxycoumarin, Chromen-2, 3-Dione, Fluorescence Properties
To cite this article
Jules Yoda, Salfo Ouédraogo, Adama Saba, 2-oxo-2H-chromen-3-yl Propionate and 2-oxo-2H-chromen-3-yl Acetate: Short-step Synthesis, Characterization and Fluorescence Properties, Science Journal of Chemistry. Vol. 7, No. 4, 2019, pp. 77-81. doi: 10.11648/j.sjc.20190704.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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