Volume 7, Issue 3, June 2019, Page: 67-71
Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin
Olawale Folorunso Akinyele, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Oluwatola Akinnusi, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Adekunle Ajayeoba, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Ayowole Olaolu Ayeni, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Lateefah Moyosore Durosinmi, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Received: Jun. 12, 2019;       Accepted: Jul. 23, 2019;       Published: Sep. 17, 2019
DOI: 10.11648/j.sjc.20190703.13      View  34      Downloads  47
Abstract
Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
Keywords
Antimicrobial, Aroylhydrazone (HL), Aspirin (HASA), Carboxylate, Azomethine
To cite this article
Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi, Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin, Science Journal of Chemistry. Vol. 7, No. 3, 2019, pp. 67-71. doi: 10.11648/j.sjc.20190703.13
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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